Assay Detail
Binding
CHEMBL3375970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human alpha7 nAChR expressed in Xenopus oocytes assessed as inhibition of Ach-evoked current after 5 mins by voltage-clamp technique
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.44 | 5.48 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1836968 | — | — | 2 | 5.48 |
| CHEMBL3355199 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1836968 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3355199 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL1836968 | — | Inhibition | - | % | - |