Assay Detail
Functional
CHEMBL3376036
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Antimalarial activity against chloroquine /mefloquine/pyrimethamine-resistant Plasmodium falciparum C235 by malaria SYBR green 1-based fluorescence (MSF) assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.42 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.89 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 7.11 |
| CHEMBL3354445 | — | — | 1 | 7.10 |
| CHEMBL3354446 | — | — | 1 | 7.10 |
| CHEMBL3354447 | — | — | 1 | 7.06 |
| CHEMBL3354449 | — | — | 1 | 6.82 |
| CHEMBL3354450 | — | — | 1 | 6.82 |
| CHEMBL3354448 | — | — | 1 | 6.75 |
| CHEMBL3354454 | — | — | 1 | 6.66 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.64 |
| CHEMBL3354451 | — | — | 1 | 6.58 |
| CHEMBL3354455 | — | — | 1 | 6.37 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 6.21 |
| CHEMBL3354457 | — | — | 1 | 6.21 |
| CHEMBL3354456 | — | — | 1 | 6.16 |
| CHEMBL3354452 | — | — | 1 | 5.92 |
| CHEMBL3354460 | — | — | 1 | 5.51 |
| CHEMBL518280 | — | — | 1 | 5.28 |
| CHEMBL311498 | CIANIDANOL | 4.0 | 1 | 5.23 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.89 |
| CHEMBL3354453 | — | — | 1 | - |
| CHEMBL3354458 | — | — | 1 | - |
| CHEMBL3354459 | — | — | 1 | - |
| CHEMBL3354444 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3354445 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3354446 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3354447 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3354449 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3354450 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3354448 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3354454 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3354451 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3354455 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3354457 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3354456 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3354452 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3354460 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL518280 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL311498 | CIANIDANOL | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL50 | QUERCETIN | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3354453 | — | IC50 | > | 2180.0 | nM | - |
| CHEMBL3354458 | — | IC50 | > | 2230.0 | nM | - |
| CHEMBL3354459 | — | IC50 | > | 2210.0 | nM | - |
| CHEMBL3354444 | — | IC50 | > | 2120.0 | nM | - |