Assay Detail
Functional
CHEMBL3376037
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Antigametocytocidal activity against Plasmodium falciparum NF54-pfs16-GPF early (1 to 3) gametocyte assessed as viability after 72 hrs by MitoTracker Red CM-H2XRos/micro-plate confocal imaging system
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.47 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.52 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.90 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 6.76 |
| CHEMBL3354446 | — | — | 1 | 5.17 |
| CHEMBL3354445 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL469912 | PUROMYCIN | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL3354446 | — | IC50 | = | 6790.0 | nM | 5.17 |
| CHEMBL3354445 | — | IC50 | = | 9670.0 | nM | 5.01 |