Assay Detail
Functional
CHEMBL3376045
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Cytotoxicity against human NCI-H460 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.24 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353928 | — | — | 1 | 7.52 |
| CHEMBL3353926 | — | — | 1 | 7.18 |
| CHEMBL3098604 | — | — | 1 | 6.30 |
| CHEMBL3098602 | — | — | 1 | 6.30 |
| CHEMBL3098691 | — | — | 1 | 5.66 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.47 |
| CHEMBL3098695 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353928 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3353926 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3098604 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3098602 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3098691 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3098695 | — | IC50 | = | 5400.0 | nM | 5.27 |