Assay Detail
Functional
CHEMBL3376049
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Antiprotozoan activity against Plasmodium falciparum NF54 IEF forms
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.91 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3098602 | — | — | 1 | 8.52 |
| CHEMBL3098604 | — | — | 1 | 8.22 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.22 |
| CHEMBL3098691 | — | — | 1 | 7.72 |
| CHEMBL3098695 | — | — | 1 | 7.64 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.60 |
| CHEMBL3353927 | — | — | 1 | 5.49 |
| CHEMBL3353928 | — | — | 1 | 5.49 |
| CHEMBL3353926 | — | — | 1 | 5.18 |
| CHEMBL3353925 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3098602 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3098604 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3098691 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3098695 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3353927 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL3353928 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL3353926 | — | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL3353925 | — | IC50 | = | 9660.0 | nM | 5.01 |