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Assay Detail

CHEMBL3376213

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Bifunctional epoxide hydrolase 2 (CHEMBL2409)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications.
Falck JR, Koduru SR, Mohapatra S, Manne R, Atcha KR, Atcha R, Manthati VL, Capdevila JH, Christian S, Imig JD, Campbell WB.
J Med Chem (2014) 57 : 6965 -6972
PubMed 25119815 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 7.40 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL215387 1 8.52
CHEMBL3322807 1 8.22
CHEMBL3322818 1 8.00
CHEMBL3322814 1 7.96
CHEMBL3322808 1 7.96
CHEMBL3322809 1 7.66
CHEMBL3322812 1 7.64
CHEMBL3322821 1 7.51
CHEMBL3322804 1 7.50
CHEMBL3322810 1 7.50
CHEMBL3322815 1 7.50
CHEMBL3322802 1 7.39
CHEMBL3322806 1 7.24
CHEMBL3322823 1 7.24
CHEMBL3322817 1 7.19
CHEMBL3322803 1 7.15
CHEMBL3322811 1 7.02
CHEMBL3322822 1 6.64
CHEMBL3322797 1 6.59
CHEMBL3322824 1 6.55
CHEMBL3322801 1 6.41
CHEMBL3322799 1 -
CHEMBL3322816 1 -
CHEMBL3322813 1 -
CHEMBL3322798 1 -
CHEMBL3322819 1 -
CHEMBL3322820 1 -
CHEMBL3322796 1 -
CHEMBL3322800 1 -
CHEMBL3322825 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL215387 IC50 = 3.0 nM 8.52
CHEMBL3322807 IC50 = 6.0 nM 8.22
CHEMBL3322818 IC50 = 10.0 nM 8.00
CHEMBL3322814 IC50 = 11.0 nM 7.96
CHEMBL3322808 IC50 = 11.0 nM 7.96
CHEMBL3322809 IC50 = 22.0 nM 7.66
CHEMBL3322812 IC50 = 23.0 nM 7.64
CHEMBL3322821 IC50 = 31.0 nM 7.51
CHEMBL3322804 IC50 = 32.0 nM 7.50
CHEMBL3322810 IC50 = 32.0 nM 7.50
CHEMBL3322815 IC50 = 32.0 nM 7.50
CHEMBL3322802 IC50 = 41.0 nM 7.39
CHEMBL3322806 IC50 = 57.0 nM 7.24
CHEMBL3322823 IC50 = 57.0 nM 7.24
CHEMBL3322817 IC50 = 65.0 nM 7.19
CHEMBL3322803 IC50 = 71.0 nM 7.15
CHEMBL3322811 IC50 = 96.0 nM 7.02
CHEMBL3322822 IC50 = 231.0 nM 6.64
CHEMBL3322797 IC50 = 255.0 nM 6.59
CHEMBL3322824 IC50 = 282.0 nM 6.55
CHEMBL3322801 IC50 = 392.0 nM 6.41
CHEMBL3322799 IC50 > 500.0 nM -
CHEMBL3322816 IC50 > 500.0 nM -
CHEMBL3322813 IC50 > 500.0 nM -
CHEMBL3322798 IC50 > 500.0 nM -
CHEMBL3322819 IC50 > 500.0 nM -
CHEMBL3322820 IC50 > 500.0 nM -
CHEMBL3322796 IC50 > 500.0 nM -
CHEMBL3322800 IC50 > 500.0 nM -
CHEMBL3322825 IC50 > 500.0 nM -
CHEMBL3322826 IC50 > 500.0 nM -
CHEMBL3322827 IC50 > 500.0 nM -
CHEMBL3322805 IC50 > 500.0 nM -