Assay Detail
Binding
CHEMBL3376317
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli ParE
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
DNA topoisomerase 4 subunit B (CHEMBL3329081) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: structure based design, synthesis, SAR and antimicrobial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.51 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3329318 | — | — | 1 | 6.11 |
| CHEMBL3329317 | — | — | 1 | 6.03 |
| CHEMBL3329319 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3329318 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3329317 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL3329319 | — | IC50 | = | 42000.0 | nM | 4.38 |