Assay Detail
Functional
CHEMBL3376589
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Cytotoxicity against human MCF7 cells by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.72 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329993 | EPOTHILONE A | — | 1 | 8.66 |
| CHEMBL303290 | — | — | 1 | 6.66 |
| CHEMBL3355651 | — | — | 1 | 4.85 |
| CHEMBL3355650 | — | — | 1 | - |
| CHEMBL2270066 | — | — | 1 | - |
| CHEMBL3355652 | — | — | 1 | - |
| CHEMBL443794 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329993 | EPOTHILONE A | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL303290 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3355651 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL3355650 | — | IC50 | > | 41500.0 | nM | - |
| CHEMBL2270066 | — | IC50 | > | 56800.0 | nM | - |
| CHEMBL3355652 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL443794 | — | IC50 | > | 34500.0 | nM | - |