Assay Detail
Functional
CHEMBL3376644
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Cytotoxicity against human A549 cells after 4 days under glucose-starved conditions by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxicity evaluation of 4-amino-4-dehydroxylarctigenin derivatives in glucose-starved A549 tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.13 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3354500 | — | — | 1 | 5.54 |
| CHEMBL435734 | ARCTIGENIN | — | 1 | 5.18 |
| CHEMBL3354507 | — | — | 1 | 4.66 |
| CHEMBL3354501 | — | — | 1 | - |
| CHEMBL3354502 | — | — | 1 | - |
| CHEMBL3354503 | — | — | 1 | - |
| CHEMBL3354504 | — | — | 1 | - |
| CHEMBL3354505 | — | — | 1 | - |
| CHEMBL3354506 | — | — | 1 | - |
| CHEMBL3354508 | — | — | 1 | - |
| CHEMBL3354509 | — | — | 1 | - |
| CHEMBL3354510 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3354500 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL435734 | ARCTIGENIN | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL3354507 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL3354501 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3354502 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3354503 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3354504 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3354505 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3354506 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3354508 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3354509 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3354510 | — | IC50 | > | 50000.0 | nM | - |