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Assay Detail

CHEMBL3376732

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Antagonist activity at human recombinant adenosine A3 receptor
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A3 (CHEMBL256)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

1,2,4-triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A₃ receptor antagonists. Synthesis, structure-affinity relationships and molecular modeling studies.
Catarzi D, Varano F, Poli D, Squarcialupi L, Betti M, Trincavelli L, Martini C, Dal Ben D, Thomas A, Volpini R, Colotta V.
Bioorg Med Chem (2015) 23 : 9 -21
PubMed 25497490 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.19 9.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL88147 1 9.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL88147 Ki = 0.65 nM 9.19