Assay Detail
Functional
CHEMBL3376819
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Antiplasmodial activity against Plasmodium falciparum 7G8 harboring mutations conferring drug-resistance by SYBR-green based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.08 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.89 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 8.64 |
| CHEMBL3321977 | — | — | 1 | 7.00 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.79 |
| CHEMBL3321871 | — | — | 1 | 6.73 |
| CHEMBL3321873 | — | — | 1 | 6.51 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3321977 | — | IC50 | = | 98.8 | nM | 7.00 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 163.9 | nM | 6.79 |
| CHEMBL3321871 | — | IC50 | = | 184.9 | nM | 6.73 |
| CHEMBL3321873 | — | IC50 | = | 307.1 | nM | 6.51 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 10041.7 | nM | 5.00 |