Assay Detail
Functional
CHEMBL3376821
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Antiplasmodial activity against Plasmodium falciparum SB1-A6 harboring mutations conferring drug-resistance by SYBR-green based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.62 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 7.96 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.93 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.78 |
| CHEMBL3321871 | — | — | 1 | 7.39 |
| CHEMBL3321873 | — | — | 1 | 7.06 |
| CHEMBL3321977 | — | — | 1 | - |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 11.81 | nM | 7.93 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL3321871 | — | IC50 | = | 40.5 | nM | 7.39 |
| CHEMBL3321873 | — | IC50 | = | 86.2 | nM | 7.06 |
| CHEMBL3321977 | — | IC50 | - | — | - | |
| CHEMBL1450 | ATOVAQUONE | IC50 | > | 2000.0 | nM | - |