Assay Detail
Binding
CHEMBL3376833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Trypanosoma brucei PTR1 using dihydrobiopterin and NADPH by spectrophotometric assay
71
Total Activities
71
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 59 | 6.14 | 6.87 |
| Ki(app) | 12 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318913 | — | — | 1 | 6.87 |
| CHEMBL3318208 | — | — | 1 | 6.86 |
| CHEMBL3318212 | — | — | 1 | 6.80 |
| CHEMBL3318495 | — | — | 1 | 6.72 |
| CHEMBL3318494 | — | — | 1 | 6.70 |
| CHEMBL3318922 | — | — | 1 | 6.70 |
| CHEMBL3318815 | — | — | 1 | 6.64 |
| CHEMBL3318211 | — | — | 1 | 6.64 |
| CHEMBL3318213 | — | — | 1 | 6.62 |
| CHEMBL3318821 | — | — | 1 | 6.62 |
| CHEMBL3318812 | — | — | 1 | 6.60 |
| CHEMBL3318804 | — | — | 1 | 6.58 |
| CHEMBL567351 | — | — | 1 | 6.57 |
| CHEMBL3318920 | — | — | 1 | 6.54 |
| CHEMBL3318916 | — | — | 1 | 6.54 |
| CHEMBL3318921 | — | — | 1 | 6.52 |
| CHEMBL3318822 | — | — | 1 | 6.52 |
| CHEMBL3318801 | — | — | 1 | 6.50 |
| CHEMBL3318214 | — | — | 1 | 6.46 |
| CHEMBL3318206 | — | — | 1 | 6.46 |
| CHEMBL3318803 | — | — | 1 | 6.40 |
| CHEMBL3318819 | — | — | 1 | 6.33 |
| CHEMBL3318802 | — | — | 1 | 6.32 |
| CHEMBL3318810 | — | — | 1 | 6.30 |
| CHEMBL3318806 | — | — | 1 | 6.25 |
| CHEMBL3318914 | — | — | 1 | 6.24 |
| CHEMBL3318911 | — | — | 1 | 6.24 |
| CHEMBL3318820 | — | — | 1 | 6.23 |
| CHEMBL3318207 | — | — | 1 | 6.14 |
| CHEMBL3318811 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318913 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL3318208 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL3318212 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL3318495 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL3318494 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL3318922 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL3318815 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL3318211 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL3318213 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL3318821 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL3318812 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL3318804 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL567351 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL3318916 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL3318920 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL3318921 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL3318822 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL3318801 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL3318214 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL3318206 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL3318803 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL3318819 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL3318802 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL3318810 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL3318806 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL3318914 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL3318911 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL3318820 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL3318207 | — | Ki | = | 731.0 | nM | 6.14 |
| CHEMBL3318811 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL3318493 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL3318816 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL3318809 | — | Ki | = | 1060.0 | nM | 5.97 |
| CHEMBL3318808 | — | Ki | = | 1170.0 | nM | 5.93 |
| CHEMBL3318496 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3318498 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3318497 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3318915 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL3318210 | — | Ki | = | 3317.0 | nM | 5.48 |
| CHEMBL3318486 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL3318209 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL3318499 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL3318487 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL3318491 | — | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL3319008 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL3318488 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL3319009 | — | Ki(app) | - | — | - | |
| CHEMBL3318490 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3318489 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3318823 | — | Ki(app) | - | — | - |