Assay Detail
Binding
CHEMBL3377014
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Transactivation of LXRalpha (unknown origin) expressed in CV1 cells by luciferase reporter gene assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.05 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360960 | — | — | 1 | 8.40 |
| CHEMBL3360963 | — | — | 1 | 7.75 |
| CHEMBL3360961 | — | — | 1 | 7.70 |
| CHEMBL62136 | T091317 | — | 1 | 7.55 |
| CHEMBL3360970 | — | — | 1 | 7.28 |
| CHEMBL3360968 | — | — | 1 | 7.19 |
| CHEMBL3360974 | — | — | 1 | 7.07 |
| CHEMBL3360965 | — | — | 1 | 6.92 |
| CHEMBL3360964 | — | — | 1 | 6.85 |
| CHEMBL3360973 | — | — | 1 | 6.70 |
| CHEMBL3360966 | — | — | 1 | 6.66 |
| CHEMBL3360975 | BMS-779788 | 1.0 | 1 | 6.64 |
| CHEMBL3360967 | — | — | 1 | 6.50 |
| CHEMBL3360969 | — | — | 1 | 6.27 |
| CHEMBL3360962 | — | — | 1 | 6.24 |
| CHEMBL3360971 | — | — | 1 | - |
| CHEMBL3360972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360960 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3360963 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3360961 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL62136 | T091317 | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3360970 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3360968 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3360974 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3360965 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3360964 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3360973 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3360966 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3360975 | BMS-779788 | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3360967 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3360969 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3360962 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3360971 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3360972 | — | EC50 | > | 10000.0 | nM | - |