Assay Detail
Binding
CHEMBL3377077
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assay
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 4.79 | 5.25 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 5.25 |
| CHEMBL1976696 | DIHYDROGUAIARETIC ACID | — | 1 | 5.20 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 5.14 |
| CHEMBL442022 | — | — | 1 | 5.10 |
| CHEMBL324842 | ROSMARINIC ACID | — | 1 | 5.07 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 1 | 5.07 |
| CHEMBL131680 | — | — | 1 | 4.96 |
| CHEMBL133714 | BENZYL CAFFEATE | — | 1 | 4.80 |
| CHEMBL471184 | PRENYL CAFFEATE | — | 1 | 4.68 |
| CHEMBL17347 | ETHYL CAFFEATE | — | 1 | 4.64 |
| CHEMBL133642 | — | — | 1 | 4.24 |
| CHEMBL17001 | METHYLCAFFEATE | — | 1 | 4.17 |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | 4.01 |
| CHEMBL284616 | CHLOROGENIC ACID | 2.0 | 1 | - |
| CHEMBL493921 | PHENETHYL CINNAMATE | — | 1 | - |
| CHEMBL492149 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL898 | DIFLUNISAL | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1976696 | DIHYDROGUAIARETIC ACID | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL442022 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL324842 | ROSMARINIC ACID | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL131680 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL133714 | BENZYL CAFFEATE | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL471184 | PRENYL CAFFEATE | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL17347 | ETHYL CAFFEATE | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL133642 | — | EC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL17001 | METHYLCAFFEATE | EC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL145 | CAFFEIC ACID | EC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL284616 | CHLOROGENIC ACID | Inhibition | - | % | - | |
| CHEMBL493921 | PHENETHYL CINNAMATE | Inhibition | - | % | - | |
| CHEMBL492149 | — | EC50 | - | — | - |