Assay Detail
Binding
CHEMBL3377243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DNA-PK by non-radiometric ADP-Glo assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA-dependent protein kinase catalytic subunit (CHEMBL3142) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Class II but Not Second Class-Prospects for the Development of Class II PI3K Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.95 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573339 | PI-103 | — | 1 | 8.70 |
| CHEMBL1241857 | — | — | 1 | 7.89 |
| CHEMBL1229535 | — | — | 1 | 7.19 |
| CHEMBL3218571 | — | — | 1 | 5.82 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573339 | PI-103 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1241857 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1229535 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3218571 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 6700.0 | nM | 5.17 |