Assay Detail
Functional
CHEMBL3377300
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Clofazimine analogs with antileishmanial and antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.44 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356383 | — | — | 1 | 7.20 |
| CHEMBL3356379 | — | — | 1 | 6.96 |
| CHEMBL3356394 | — | — | 1 | 6.75 |
| CHEMBL3356392 | — | — | 1 | 6.68 |
| CHEMBL3356387 | — | — | 1 | 6.68 |
| CHEMBL3356384 | — | — | 1 | 6.62 |
| CHEMBL3356382 | — | — | 1 | 6.57 |
| CHEMBL3356391 | — | — | 1 | 6.57 |
| CHEMBL3356386 | — | — | 1 | 6.57 |
| CHEMBL3356395 | — | — | 1 | 6.55 |
| CHEMBL3356377 | — | — | 1 | 6.54 |
| CHEMBL3356389 | — | — | 1 | 6.47 |
| CHEMBL3356393 | — | — | 1 | 6.46 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.44 |
| CHEMBL3356388 | — | — | 1 | 6.41 |
| CHEMBL3356385 | — | — | 1 | 6.40 |
| CHEMBL3356375 | — | — | 1 | 6.36 |
| CHEMBL3356378 | — | — | 1 | 6.35 |
| CHEMBL3356390 | — | — | 1 | 6.24 |
| CHEMBL3356376 | — | — | 1 | 6.12 |
| CHEMBL3356380 | — | — | 1 | 6.09 |
| CHEMBL3356381 | — | — | 1 | 6.02 |
| CHEMBL1292 | CLOFAZIMINE | 4.0 | 1 | 5.15 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356383 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3356379 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3356394 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3356392 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3356387 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3356384 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3356382 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3356391 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3356386 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3356395 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3356377 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3356389 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3356393 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3356388 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3356385 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3356375 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3356378 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3356390 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3356376 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3356380 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3356381 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 7020.0 | nM | 5.15 |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | - | — | - |