Assay Detail
Functional
CHEMBL3377424
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Cytotoxicity against human K562 cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.18 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318106 | — | — | 1 | 7.75 |
| CHEMBL3318100 | — | — | 1 | 7.70 |
| CHEMBL3318105 | — | — | 1 | 7.60 |
| CHEMBL3318102 | — | — | 1 | 7.52 |
| CHEMBL3318112 | — | — | 1 | 7.52 |
| CHEMBL3318107 | — | — | 1 | 7.05 |
| CHEMBL3318103 | — | — | 1 | 6.30 |
| CHEMBL3318108 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318106 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3318100 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3318105 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3318102 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3318112 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3318107 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3318103 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3318108 | — | IC50 | = | 950.0 | nM | 6.02 |