Assay Detail
Binding
CHEMBL3377628
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Inhibition of chimeric carbonic anhydrase 9 (unknown origin) expressing with full length CA2 (1 to 260) at pH7 and 37 degC by isothermal titration calorimetry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.88 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3359181 | — | — | 1 | 8.14 |
| CHEMBL2333416 | — | — | 1 | 7.92 |
| CHEMBL2333417 | — | — | 1 | 7.85 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL3359179 | — | — | 1 | 7.66 |
| CHEMBL3359180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3359181 | — | Kd | = | 7.3 | nM | 8.14 |
| CHEMBL2333416 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL2333417 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL20 | ACETAZOLAMIDE | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL3359179 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL3359180 | — | Kd | - | — | - |