Assay Detail
Binding
CHEMBL3377632
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase 2 at pH7 and 25 degC by stopped-flow kinetic inhibition assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.19 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.00 |
| CHEMBL3359181 | — | — | 1 | 7.54 |
| CHEMBL3359179 | — | — | 1 | 6.04 |
| CHEMBL3359180 | — | — | 1 | - |
| CHEMBL2333416 | — | — | 1 | - |
| CHEMBL2333417 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL3359181 | — | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL3359179 | — | Kd | = | 910.0 | nM | 6.04 |
| CHEMBL3359180 | — | Kd | - | — | - | |
| CHEMBL2333416 | — | Kd | < | 5.0 | nM | - |
| CHEMBL2333417 | — | Kd | - | — | - |