Assay Detail
Binding
CHEMBL3377720
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of P-gp-mediated resistance to doxorubicin in human SW620 cells assessed as reduction in doxorubin IC50 at 400 nM after 72 hrs by SRB assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Polyoxypregnane steroids from the stems of Marsdenia tenacissima.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.00 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1086218 | VALSPODAR | 3.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1086218 | VALSPODAR | IC50 | = | 100.0 | nM | 7.00 |