Assay Detail
Functional
CHEMBL3378374
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Cytotoxicity against human U251 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-251 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Semisynthesis of triptolide analogues: effect of B-ring substituents on cytotoxic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.12 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205190 | TRIPTONIDE | — | 1 | 7.51 |
| CHEMBL463763 | TRIPTOLIDE | 3.0 | 1 | 7.48 |
| CHEMBL3358845 | — | — | 1 | 6.77 |
| CHEMBL3358852 | — | — | 1 | 6.71 |
| CHEMBL3358844 | — | — | 1 | 6.37 |
| CHEMBL3358841 | — | — | 1 | 6.31 |
| CHEMBL3358846 | — | — | 1 | 6.25 |
| CHEMBL562667 | — | — | 1 | 6.18 |
| CHEMBL3358850 | — | — | 1 | 6.14 |
| CHEMBL3358842 | — | — | 1 | 6.10 |
| CHEMBL3358847 | — | — | 1 | 6.03 |
| CHEMBL3358843 | — | — | 1 | 5.99 |
| CHEMBL3358855 | — | — | 1 | 5.80 |
| CHEMBL3358849 | — | — | 1 | 5.79 |
| CHEMBL3358848 | — | — | 1 | 5.69 |
| CHEMBL3358854 | — | — | 1 | 5.53 |
| CHEMBL3358851 | — | — | 1 | 5.30 |
| CHEMBL561903 | — | — | 1 | 5.26 |
| CHEMBL3358853 | — | — | 1 | 5.01 |
| CHEMBL3358856 | — | — | 1 | - |
| CHEMBL3358857 | — | — | 1 | - |
| CHEMBL3358858 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205190 | TRIPTONIDE | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL463763 | TRIPTOLIDE | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3358845 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3358852 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL3358844 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL3358841 | — | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL3358846 | — | IC50 | = | 558.0 | nM | 6.25 |
| CHEMBL562667 | — | IC50 | = | 657.0 | nM | 6.18 |
| CHEMBL3358850 | — | IC50 | = | 718.0 | nM | 6.14 |
| CHEMBL3358842 | — | IC50 | = | 796.0 | nM | 6.10 |
| CHEMBL3358847 | — | IC50 | = | 925.0 | nM | 6.03 |
| CHEMBL3358843 | — | IC50 | = | 1031.0 | nM | 5.99 |
| CHEMBL3358855 | — | IC50 | = | 1585.0 | nM | 5.80 |
| CHEMBL3358849 | — | IC50 | = | 1632.0 | nM | 5.79 |
| CHEMBL3358848 | — | IC50 | = | 2037.0 | nM | 5.69 |
| CHEMBL3358854 | — | IC50 | = | 2966.0 | nM | 5.53 |
| CHEMBL3358851 | — | IC50 | = | 5044.0 | nM | 5.30 |
| CHEMBL561903 | — | IC50 | = | 5466.0 | nM | 5.26 |
| CHEMBL3358853 | — | IC50 | = | 9855.0 | nM | 5.01 |
| CHEMBL3358856 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3358857 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3358858 | — | IC50 | > | 10000.0 | nM | - |