Assay Detail
Functional
CHEMBL3378642
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Antagonist activity at mouse SSTR3 expressed in CHO cells assessed as cAMP level by fluorescence analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.24 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3323084 | — | — | 1 | 9.80 |
| CHEMBL3323076 | — | — | 1 | 9.46 |
| CHEMBL3323074 | — | — | 1 | 9.44 |
| CHEMBL3323072 | — | — | 1 | 9.24 |
| CHEMBL3323082 | — | — | 1 | 9.14 |
| CHEMBL3323078 | — | — | 1 | 8.81 |
| CHEMBL3323085 | — | — | 1 | 8.54 |
| CHEMBL3323073 | — | — | 1 | 8.46 |
| CHEMBL3323077 | — | — | 1 | 8.08 |
| CHEMBL3323079 | — | — | 1 | 7.85 |
| CHEMBL3323075 | — | — | 1 | 7.83 |
| CHEMBL3323083 | — | — | 1 | 7.77 |
| CHEMBL3323080 | — | — | 1 | 7.47 |
| CHEMBL3323086 | — | — | 1 | 7.24 |
| CHEMBL3323081 | — | — | 1 | 6.96 |
| CHEMBL3323087 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3323084 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL3323076 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL3323074 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL3323072 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL3323082 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL3323078 | — | IC50 | = | 1.53 | nM | 8.81 |
| CHEMBL3323085 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3323073 | — | IC50 | = | 3.48 | nM | 8.46 |
| CHEMBL3323077 | — | IC50 | = | 8.37 | nM | 8.08 |
| CHEMBL3323079 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL3323075 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL3323083 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL3323080 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3323086 | — | IC50 | = | 57.1 | nM | 7.24 |
| CHEMBL3323081 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL3323087 | — | IC50 | = | 1863.0 | nM | 5.73 |