Assay Detail
Binding
CHEMBL3378755
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Inhibition of MDR1 (unknown origin) expressed in MDCK cells after 30 mins by Calcein-AM assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.47 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3317923 | — | — | 1 | 6.70 |
| CHEMBL3317932 | — | — | 1 | 6.51 |
| CHEMBL3317921 | — | — | 1 | 6.27 |
| CHEMBL3317924 | — | — | 1 | 6.17 |
| CHEMBL3317919 | — | — | 1 | 6.01 |
| CHEMBL260599 | — | — | 1 | 5.99 |
| CHEMBL3317933 | — | — | 1 | 5.91 |
| CHEMBL3317918 | — | — | 1 | 5.89 |
| CHEMBL3317935 | — | — | 1 | 5.56 |
| CHEMBL3317925 | — | — | 1 | 5.53 |
| CHEMBL3317931 | — | — | 1 | 5.50 |
| CHEMBL3317927 | — | — | 1 | 5.48 |
| CHEMBL3317922 | — | — | 1 | 5.36 |
| CHEMBL3317928 | — | — | 1 | 5.28 |
| CHEMBL3317937 | — | — | 1 | 5.18 |
| CHEMBL3317920 | — | — | 1 | 5.09 |
| CHEMBL3317926 | — | — | 1 | 5.05 |
| CHEMBL3317929 | — | — | 1 | 5.04 |
| CHEMBL3317936 | — | — | 1 | 4.73 |
| CHEMBL3317938 | — | — | 1 | 4.67 |
| CHEMBL3317930 | — | — | 1 | 4.22 |
| CHEMBL3317934 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3317923 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3317932 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3317921 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3317924 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3317919 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL260599 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3317933 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL3317918 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3317935 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL3317925 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL3317931 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3317927 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3317922 | — | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL3317928 | — | IC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL3317937 | — | IC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL3317920 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL3317926 | — | IC50 | = | 8920.0 | nM | 5.05 |
| CHEMBL3317929 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3317936 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL3317938 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL3317930 | — | IC50 | = | 60100.0 | nM | 4.22 |
| CHEMBL3317934 | — | IC50 | = | 67500.0 | nM | 4.17 |