Assay Detail
Functional
CHEMBL3379218
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Antiproliferative activity against human HepG2 cells after 24 hrs by Alamar blue assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.33 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3337645 | — | — | 1 | 4.51 |
| CHEMBL3337649 | — | — | 1 | 4.39 |
| CHEMBL105867 | — | — | 1 | 4.24 |
| CHEMBL3337647 | — | — | 1 | 4.19 |
| CHEMBL3337648 | — | — | 1 | - |
| CHEMBL232300 | — | — | 1 | - |
| CHEMBL3337646 | — | — | 1 | - |
| CHEMBL93103 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3337645 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3337649 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL105867 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL3337647 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL3337648 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL232300 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL3337646 | — | IC50 | - | — | - | |
| CHEMBL93103 | — | IC50 | - | — | - |