Assay Detail
Binding
CHEMBL3379241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(+)-MK-801 from NMDA receptor PCP binding site in guinea pig brain cortex membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted κ-opioid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.98 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344151 | DIZOCILPINE MALEATE | -1.0 | 1 | 8.54 |
| CHEMBL1165411 | DEXOXADROL | 2.0 | 1 | 7.42 |
| CHEMBL3323509 | — | — | 1 | - |
| CHEMBL3323512 | — | — | 1 | - |
| CHEMBL3323515 | — | — | 1 | - |
| CHEMBL3323516 | — | — | 1 | - |
| CHEMBL3323519 | — | — | 1 | - |
| CHEMBL3323522 | — | — | 1 | - |
| CHEMBL3323527 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344151 | DIZOCILPINE MALEATE | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL1165411 | DEXOXADROL | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL3323509 | — | Ki | - | — | - | |
| CHEMBL3323512 | — | Ki | - | — | - | |
| CHEMBL3323515 | — | Ki | - | — | - | |
| CHEMBL3323516 | — | Ki | - | — | - | |
| CHEMBL3323519 | — | Ki | - | — | - | |
| CHEMBL3323522 | — | Ki | - | — | - | |
| CHEMBL3323527 | — | Ki | - | — | - |