Assay Detail
Binding
CHEMBL3379351
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]IABN from human D2LR expressed in HEK293 cell membranes by gamma counting method
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 6.19 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3322994 | — | — | 1 | 7.92 |
| CHEMBL3322993 | — | — | 1 | 7.72 |
| CHEMBL3322995 | — | — | 1 | 6.79 |
| CHEMBL3322992 | — | — | 1 | 6.75 |
| CHEMBL3323010 | — | — | 1 | 6.72 |
| CHEMBL3322996 | — | — | 1 | 6.72 |
| CHEMBL3323114 | — | — | 1 | 6.53 |
| CHEMBL3323112 | — | — | 1 | 6.52 |
| CHEMBL3323013 | — | — | 1 | 6.47 |
| CHEMBL3323116 | — | — | 1 | 6.47 |
| CHEMBL3323009 | — | — | 1 | 6.44 |
| CHEMBL3323008 | — | — | 1 | 6.44 |
| CHEMBL3323015 | — | — | 1 | 6.36 |
| CHEMBL3323016 | — | — | 1 | 6.35 |
| CHEMBL3323018 | — | — | 1 | 6.32 |
| CHEMBL3323011 | — | — | 1 | 6.29 |
| CHEMBL3323019 | — | — | 1 | 6.28 |
| CHEMBL3322998 | — | — | 1 | 6.24 |
| CHEMBL3323017 | — | — | 1 | 6.18 |
| CHEMBL3323014 | — | — | 1 | 6.17 |
| CHEMBL3323115 | — | — | 1 | 6.09 |
| CHEMBL3323012 | — | — | 1 | 6.04 |
| CHEMBL3323113 | — | — | 1 | 6.03 |
| CHEMBL3323003 | — | — | 1 | 5.95 |
| CHEMBL3322997 | — | — | 1 | 5.88 |
| CHEMBL3323004 | — | — | 1 | 5.84 |
| CHEMBL3323117 | — | — | 1 | 5.82 |
| CHEMBL3323002 | — | — | 1 | 5.81 |
| CHEMBL3323001 | — | — | 1 | 5.72 |
| CHEMBL3323006 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3322994 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3322993 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3322995 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL3322992 | — | Ki | = | 178.0 | nM | 6.75 |
| CHEMBL3323010 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL3322996 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL3323114 | — | Ki | = | 298.0 | nM | 6.53 |
| CHEMBL3323112 | — | Ki | = | 301.0 | nM | 6.52 |
| CHEMBL3323013 | — | Ki | = | 336.0 | nM | 6.47 |
| CHEMBL3323116 | — | Ki | = | 337.0 | nM | 6.47 |
| CHEMBL3323009 | — | Ki | = | 361.0 | nM | 6.44 |
| CHEMBL3323008 | — | Ki | = | 366.0 | nM | 6.44 |
| CHEMBL3323015 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL3323016 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL3323018 | — | Ki | = | 481.0 | nM | 6.32 |
| CHEMBL3323011 | — | Ki | = | 511.0 | nM | 6.29 |
| CHEMBL3323019 | — | Ki | = | 527.0 | nM | 6.28 |
| CHEMBL3322998 | — | Ki | = | 572.0 | nM | 6.24 |
| CHEMBL3323017 | — | Ki | = | 655.0 | nM | 6.18 |
| CHEMBL3323014 | — | Ki | = | 683.0 | nM | 6.17 |
| CHEMBL3323115 | — | Ki | = | 809.0 | nM | 6.09 |
| CHEMBL3323012 | — | Ki | = | 913.0 | nM | 6.04 |
| CHEMBL3323113 | — | Ki | = | 934.0 | nM | 6.03 |
| CHEMBL3323003 | — | Ki | = | 1133.0 | nM | 5.95 |
| CHEMBL3322997 | — | Ki | = | 1303.0 | nM | 5.88 |
| CHEMBL3323004 | — | Ki | = | 1452.0 | nM | 5.84 |
| CHEMBL3323117 | — | Ki | = | 1510.0 | nM | 5.82 |
| CHEMBL3323002 | — | Ki | = | 1563.0 | nM | 5.81 |
| CHEMBL3323001 | — | Ki | = | 1883.0 | nM | 5.72 |
| CHEMBL3323006 | — | Ki | = | 3646.0 | nM | 5.44 |
| CHEMBL3323007 | — | Ki | = | 4604.0 | nM | 5.34 |
| CHEMBL3323000 | — | Ki | = | 4983.0 | nM | 5.30 |
| CHEMBL3322999 | — | Ki | = | 13567.0 | nM | 4.87 |
| CHEMBL3323005 | — | Ki | = | 24938.0 | nM | 4.60 |