Assay Detail
Binding
CHEMBL3379359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-RTI-55 from recombinant NET (unknown origin) expressed in HEK cells by saturation binding analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.65 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3323095 | — | — | 1 | 8.47 |
| CHEMBL3323106 | — | — | 1 | 8.17 |
| CHEMBL3323100 | — | — | 1 | 8.11 |
| CHEMBL3323181 | — | — | 1 | 8.08 |
| CHEMBL3323102 | — | — | 1 | 8.06 |
| CHEMBL3323104 | — | — | 1 | 7.96 |
| CHEMBL3323105 | — | — | 1 | 7.89 |
| CHEMBL3323184 | — | — | 1 | 7.80 |
| CHEMBL3323107 | — | — | 1 | 7.72 |
| CHEMBL3323108 | — | — | 1 | 7.66 |
| CHEMBL3323176 | — | — | 1 | 7.39 |
| CHEMBL3323182 | — | — | 1 | 7.03 |
| CHEMBL3323177 | — | — | 1 | 6.75 |
| CHEMBL3323109 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3323095 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3323106 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL3323100 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL3323181 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL3323102 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL3323104 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3323105 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3323184 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3323107 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3323108 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3323176 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3323182 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL3323177 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3323109 | — | IC50 | = | 1000.0 | nM | 6.00 |