Assay Detail
Binding
CHEMBL3379478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC1 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
ST7612AA1, a thioacetate-ω(γ-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.18 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356916 | — | — | 1 | 8.70 |
| CHEMBL3356924 | — | — | 1 | 8.52 |
| CHEMBL3356923 | — | — | 1 | 8.40 |
| CHEMBL3356922 | — | — | 1 | 8.30 |
| CHEMBL3353927 | — | — | 1 | 8.30 |
| CHEMBL3356527 | — | — | 1 | 8.15 |
| CHEMBL3356925 | — | — | 1 | 8.15 |
| CHEMBL3356917 | — | — | 1 | 8.10 |
| CHEMBL3356929 | — | — | 1 | 8.10 |
| CHEMBL3356524 | — | — | 1 | 8.00 |
| CHEMBL3356526 | — | — | 1 | 7.96 |
| CHEMBL3356915 | — | — | 1 | 7.92 |
| CHEMBL3356919 | — | — | 1 | 7.89 |
| CHEMBL3356523 | — | — | 1 | 7.82 |
| CHEMBL3356918 | — | — | 1 | 7.62 |
| CHEMBL3356927 | — | — | 1 | 7.50 |
| CHEMBL3356926 | — | — | 1 | 7.28 |
| CHEMBL3356921 | — | — | 1 | 7.24 |
| CHEMBL3356928 | — | — | 1 | 7.13 |
| CHEMBL3356937 | — | — | 1 | 7.04 |
| CHEMBL3356920 | — | — | 1 | 7.00 |
| CHEMBL3356931 | — | — | 1 | 6.80 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.59 |
| CHEMBL325676 | — | — | 1 | 6.54 |
| CHEMBL326433 | 8-MERCAPTO-OCTANOIC ACID PHENYLAMIDE | — | 1 | 6.53 |
| CHEMBL3356933 | — | — | 1 | 6.41 |
| CHEMBL3356935 | — | — | 1 | 6.30 |
| CHEMBL109654 | — | — | 1 | 6.10 |
| CHEMBL3356930 | — | — | 1 | 6.06 |
| CHEMBL3356938 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356916 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3356924 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3356923 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3356922 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3353927 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3356527 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3356925 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3356917 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3356929 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3356524 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3356526 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3356915 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3356919 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3356523 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3356918 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3356927 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3356926 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3356921 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3356928 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3356937 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3356920 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3356931 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL325676 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL326433 | 8-MERCAPTO-OCTANOIC ACID PHENYLAMIDE | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL3356933 | — | IC50 | = | 386.0 | nM | 6.41 |
| CHEMBL3356935 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL109654 | — | IC50 | = | 791.0 | nM | 6.10 |
| CHEMBL3356930 | — | IC50 | = | 865.0 | nM | 6.06 |
| CHEMBL3356938 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL3356939 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3356934 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL3356936 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL3356932 | — | IC50 | = | 5960.0 | nM | 5.22 |