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Assay Detail

CHEMBL3379491

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human NCI-H460 cells after 24 hrs by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H460
Confidence 1 — Organism
Curated By Autocuration

Target

NCI-H460 (CHEMBL396)
Type CELL-LINE
Organism Homo sapiens

Publication

ST7612AA1, a thioacetate-ω(γ-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.
Giannini G, Vesci L, Battistuzzi G, Vignola D, Milazzo FM, Guglielmi MB, Barbarino M, Santaniello M, Fantò N, Mor M, Rivara S, Pala D, Taddei M, Pisano C, Cabri W.
J Med Chem (2014) 57 : 8358 -8377
PubMed 25233084 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.80 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3353928 1 7.52
CHEMBL3356946 1 7.40
CHEMBL3356948 1 7.30
CHEMBL3356944 1 7.22
CHEMBL3356945 1 7.22
CHEMBL3353926 1 7.16
CHEMBL3356940 1 7.00
CHEMBL3356947 1 7.00
CHEMBL3356941 1 6.29
CHEMBL3356942 1 5.43
CHEMBL3356943 1 5.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3353928 IC50 = 30.0 nM 7.52
CHEMBL3356946 IC50 = 40.0 nM 7.40
CHEMBL3356948 IC50 = 50.0 nM 7.30
CHEMBL3356944 IC50 = 60.0 nM 7.22
CHEMBL3356945 IC50 = 60.0 nM 7.22
CHEMBL3353926 IC50 = 70.0 nM 7.16
CHEMBL3356940 IC50 = 100.0 nM 7.00
CHEMBL3356947 IC50 = 100.0 nM 7.00
CHEMBL3356941 IC50 = 510.0 nM 6.29
CHEMBL3356942 IC50 = 3700.0 nM 5.43
CHEMBL3356943 IC50 = 5400.0 nM 5.27