Assay Detail
Binding
CHEMBL3379494
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Inhibition of HDAC-mediated histone H4 deacetylation in human NCI-H460 cells after 3 hrs by Western blot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
ST7612AA1, a thioacetate-ω(γ-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.60 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353926 | — | — | 1 | 8.30 |
| CHEMBL3356948 | — | — | 1 | 7.51 |
| CHEMBL3356940 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353926 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3356948 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3356940 | — | IC50 | = | 100.0 | nM | 7.00 |