Assay Detail
Binding
CHEMBL3379628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-a]pyrazines as ATR Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.94 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355072 | — | — | 1 | 9.52 |
| CHEMBL3355074 | — | — | 1 | 9.40 |
| CHEMBL3355069 | — | — | 1 | 9.30 |
| CHEMBL3355071 | — | — | 1 | 9.30 |
| CHEMBL3355070 | — | — | 1 | 9.00 |
| CHEMBL3355073 | — | — | 1 | 9.00 |
| CHEMBL3352844 | — | — | 1 | 8.70 |
| CHEMBL3355068 | — | — | 1 | 7.58 |
| CHEMBL3355075 | — | — | 1 | 7.54 |
| CHEMBL3355079 | — | — | 1 | 7.39 |
| CHEMBL3355080 | — | — | 1 | 7.19 |
| CHEMBL3355076 | — | — | 1 | 6.36 |
| CHEMBL3355078 | — | — | 1 | 5.68 |
| CHEMBL3355077 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355072 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3355074 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3355069 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3355071 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3355070 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3355073 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3352844 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3355068 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3355075 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3355079 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3355080 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3355076 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3355078 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3355077 | — | IC50 | = | 6200.0 | nM | 5.21 |