Assay Detail
Binding
CHEMBL3379633
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Inhibition of human ERG by automated whole cell electrophysiology
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-a]pyrazines as ATR Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.36 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355072 | — | — | 1 | 5.82 |
| CHEMBL3355074 | — | — | 1 | 4.90 |
| CHEMBL3355073 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355072 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3355074 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3355073 | — | IC50 | > | 30000.0 | nM | - |