Assay Detail
Binding
CHEMBL3379807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of beta-secretase (unknown origin) using 150 nM Rhodamine-EVNLDAEFK-quencher substrate proteolysis by fluorescence resonance energy transfer assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.69 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.28 |
| CHEMBL3326704 | — | — | 1 | 4.76 |
| CHEMBL3327246 | — | — | 1 | 4.70 |
| CHEMBL3326709 | — | — | 1 | 4.65 |
| CHEMBL3326698 | — | — | 1 | 4.40 |
| CHEMBL3327247 | — | — | 1 | 4.37 |
| CHEMBL3326707 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3326704 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL3327246 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL3326709 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL3326698 | — | IC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL3327247 | — | IC50 | = | 42800.0 | nM | 4.37 |
| CHEMBL3326707 | — | IC50 | > | 100000.0 | nM | - |