Assay Detail
Binding
CHEMBL3379836
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Inhibition of Bacillus pasteurii urease using urea substrate assessed as reduction in ammonia production after 15 mins by indophenol's method
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sporosarcina pasteurii |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.63 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290406 | — | — | 1 | 5.79 |
| CHEMBL3309730 | — | — | 1 | 5.17 |
| CHEMBL3309731 | — | — | 1 | 4.97 |
| CHEMBL566267 | — | — | 1 | 4.84 |
| CHEMBL3309724 | — | — | 1 | 4.80 |
| CHEMBL3309345 | — | — | 1 | 4.80 |
| CHEMBL3309735 | — | — | 1 | 4.74 |
| CHEMBL3309343 | — | — | 1 | 4.74 |
| CHEMBL3309734 | — | — | 1 | 4.72 |
| CHEMBL260876 | THIOUREA | — | 1 | 4.68 |
| CHEMBL357461 | — | — | 1 | 4.67 |
| CHEMBL3309342 | — | — | 1 | 4.67 |
| CHEMBL3290407 | — | — | 1 | 4.64 |
| CHEMBL3290410 | — | — | 1 | 4.60 |
| CHEMBL3309733 | — | — | 1 | 4.53 |
| CHEMBL3290405 | — | — | 1 | 4.49 |
| CHEMBL3309736 | — | — | 1 | 4.49 |
| CHEMBL3309729 | — | — | 1 | 4.49 |
| CHEMBL3309732 | — | — | 1 | 4.38 |
| CHEMBL3309726 | — | — | 1 | 4.37 |
| CHEMBL3309725 | — | — | 1 | 4.36 |
| CHEMBL3309341 | — | — | 1 | 4.33 |
| CHEMBL3309340 | — | — | 1 | 4.33 |
| CHEMBL3309728 | — | — | 1 | 4.30 |
| CHEMBL269821 | — | — | 1 | 4.23 |
| CHEMBL3309344 | — | — | 1 | 4.20 |
| CHEMBL3309727 | — | — | 1 | - |
| CHEMBL1714005 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290406 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL3309730 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3309731 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL566267 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL3309724 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3309345 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3309735 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL3309343 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL3309734 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL260876 | THIOUREA | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL357461 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL3309342 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL3290407 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL3290410 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL3309733 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL3290405 | — | IC50 | = | 32100.0 | nM | 4.49 |
| CHEMBL3309736 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL3309729 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL3309732 | — | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL3309726 | — | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL3309725 | — | IC50 | = | 43300.0 | nM | 4.36 |
| CHEMBL3309341 | — | IC50 | = | 47300.0 | nM | 4.33 |
| CHEMBL3309340 | — | IC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL3309728 | — | IC50 | = | 50300.0 | nM | 4.30 |
| CHEMBL269821 | — | IC50 | = | 58500.0 | nM | 4.23 |
| CHEMBL3309344 | — | IC50 | = | 62800.0 | nM | 4.20 |
| CHEMBL3309727 | — | IC50 | = | 137200.0 | nM | - |
| CHEMBL1714005 | — | IC50 | = | 170800.0 | nM | - |