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Assay Detail

CHEMBL3379838

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human MAOB expressed in baculovirus-infected BTI insect cells assessed as H2O2 production by resorufin dye based fluorimetric method
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of some novel hydrazone and 2-pyrazoline derivatives: monoamine oxidase inhibitory activities and docking studies.
Evranos-Aksöz B, Yabanoğlu-Çiftçi S, Uçar G, Yelekçi K, Ertan R.
Bioorg Med Chem Lett (2014) 24 : 3278 -3284
PubMed 24986657 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 28 5.42 6.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3310023 1 6.28
CHEMBL3310022 1 6.16
CHEMBL3310024 1 6.12
CHEMBL3310005 1 6.12
CHEMBL3310027 1 6.06
CHEMBL3310029 1 6.05
CHEMBL3310021 1 6.01
CHEMBL3310025 1 6.00
CHEMBL3309741 1 6.00
CHEMBL3310026 1 5.98
CHEMBL86304 MOCLOBEMIDE 4.0 1 5.87
CHEMBL3310028 1 5.83
CHEMBL3310011 1 5.70
CHEMBL3309737 1 5.38
CHEMBL3309739 1 5.28
CHEMBL2005326 1 5.26
CHEMBL3309738 1 5.16
CHEMBL2297676 1 5.14
CHEMBL389840 1 5.11
CHEMBL374741 1 4.86
CHEMBL3310013 1 4.85
CHEMBL140711 1 4.83
CHEMBL3310007 1 4.70
CHEMBL7973 1 4.57
CHEMBL3310017 1 4.53
CHEMBL3310015 1 4.22
CHEMBL3310009 1 4.14
CHEMBL3310019 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3310023 Ki = 520.0 nM 6.28
CHEMBL3310022 Ki = 700.0 nM 6.16
CHEMBL3310024 Ki = 760.0 nM 6.12
CHEMBL3310005 Ki = 750.0 nM 6.12
CHEMBL3310027 Ki = 870.0 nM 6.06
CHEMBL3310029 Ki = 900.0 nM 6.05
CHEMBL3310021 Ki = 980.0 nM 6.01
CHEMBL3310025 Ki = 990.0 nM 6.00
CHEMBL3309741 Ki = 990.0 nM 6.00
CHEMBL3310026 Ki = 1050.0 nM 5.98
CHEMBL86304 MOCLOBEMIDE Ki = 1340.0 nM 5.87
CHEMBL3310028 Ki = 1480.0 nM 5.83
CHEMBL3310011 Ki = 2000.0 nM 5.70
CHEMBL3309737 Ki = 4220.0 nM 5.38
CHEMBL3309739 Ki = 5230.0 nM 5.28
CHEMBL2005326 Ki = 5550.0 nM 5.26
CHEMBL3309738 Ki = 7000.0 nM 5.16
CHEMBL2297676 Ki = 7220.0 nM 5.14
CHEMBL389840 Ki = 7700.0 nM 5.11
CHEMBL374741 Ki = 13900.0 nM 4.86
CHEMBL3310013 Ki = 14000.0 nM 4.85
CHEMBL140711 Ki = 14900.0 nM 4.83
CHEMBL3310007 Ki = 20000.0 nM 4.70
CHEMBL7973 Ki = 27000.0 nM 4.57
CHEMBL3310017 Ki = 29660.0 nM 4.53
CHEMBL3310015 Ki = 60000.0 nM 4.22
CHEMBL3310009 Ki = 72000.0 nM 4.14
CHEMBL3310019 Ki = 1640000.0 nM -