Assay Detail
Binding
CHEMBL3379900
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]IABN from human D3R E90Q mutant expressed in HEK293 cell membranes by gamma counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.78 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3323114 | — | — | 1 | 7.92 |
| CHEMBL3323112 | — | — | 1 | 7.72 |
| CHEMBL3323011 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3323114 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3323112 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3323011 | — | Ki | = | 20.0 | nM | 7.70 |