Assay Detail
Binding
CHEMBL3380010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced protein/transthyretin interaction by HTRF assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.89 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3359024 | — | — | 1 | 9.92 |
| CHEMBL1230001 | — | — | 1 | 9.81 |
| CHEMBL3359022 | — | — | 1 | 9.75 |
| CHEMBL3359023 | — | — | 1 | 9.63 |
| CHEMBL3359017 | — | — | 1 | 9.54 |
| CHEMBL3359014 | — | — | 1 | 9.53 |
| CHEMBL3359019 | — | — | 1 | 9.47 |
| CHEMBL3359015 | — | — | 1 | 9.32 |
| CHEMBL3359005 | — | — | 1 | 9.26 |
| CHEMBL3359028 | — | — | 1 | 9.08 |
| CHEMBL3359020 | — | — | 1 | 8.81 |
| CHEMBL3358470 | — | — | 1 | 8.58 |
| CHEMBL3358466 | — | — | 1 | 8.50 |
| CHEMBL3358465 | — | — | 1 | 8.40 |
| CHEMBL3358464 | — | — | 1 | 8.28 |
| CHEMBL3359026 | — | — | 1 | 8.28 |
| CHEMBL3359025 | — | — | 1 | 8.17 |
| CHEMBL3358463 | — | — | 1 | 8.17 |
| CHEMBL3359029 | — | — | 1 | 8.08 |
| CHEMBL3359011 | — | — | 1 | 8.08 |
| CHEMBL3359027 | — | — | 1 | 8.04 |
| CHEMBL3359013 | — | — | 1 | - |
| CHEMBL3359012 | — | — | 1 | - |
| CHEMBL3359016 | — | — | 1 | - |
| CHEMBL3359018 | — | — | 1 | - |
| CHEMBL3359010 | — | — | 1 | - |
| CHEMBL3359009 | — | — | 1 | - |
| CHEMBL3359021 | — | — | 1 | - |
| CHEMBL3359008 | — | — | 1 | - |
| CHEMBL3359007 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3359024 | — | IC50 | = | 0.121 | nM | 9.92 |
| CHEMBL1230001 | — | IC50 | = | 0.155 | nM | 9.81 |
| CHEMBL3359022 | — | IC50 | = | 0.179 | nM | 9.75 |
| CHEMBL3359023 | — | IC50 | = | 0.235 | nM | 9.63 |
| CHEMBL3359017 | — | IC50 | = | 0.285 | nM | 9.54 |
| CHEMBL3359014 | — | IC50 | = | 0.294 | nM | 9.53 |
| CHEMBL3359019 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL3359015 | — | IC50 | = | 0.481 | nM | 9.32 |
| CHEMBL3359005 | — | IC50 | = | 0.554 | nM | 9.26 |
| CHEMBL3359028 | — | IC50 | = | 0.829 | nM | 9.08 |
| CHEMBL3359020 | — | IC50 | = | 1.55 | nM | 8.81 |
| CHEMBL3358470 | — | IC50 | = | 2.65 | nM | 8.58 |
| CHEMBL3358466 | — | IC50 | = | 3.13 | nM | 8.50 |
| CHEMBL3358465 | — | IC50 | = | 3.94 | nM | 8.40 |
| CHEMBL3359026 | — | IC50 | = | 5.26 | nM | 8.28 |
| CHEMBL3358464 | — | IC50 | = | 5.31 | nM | 8.28 |
| CHEMBL3358463 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL3359025 | — | IC50 | = | 6.82 | nM | 8.17 |
| CHEMBL3359029 | — | IC50 | = | 8.34 | nM | 8.08 |
| CHEMBL3359011 | — | IC50 | = | 8.38 | nM | 8.08 |
| CHEMBL3359027 | — | IC50 | = | 9.19 | nM | 8.04 |
| CHEMBL3358467 | — | IC50 | - | — | - | |
| CHEMBL3358468 | — | IC50 | - | — | - | |
| CHEMBL3358469 | — | IC50 | - | — | - | |
| CHEMBL3358471 | — | IC50 | - | — | - | |
| CHEMBL3359006 | — | IC50 | - | — | - | |
| CHEMBL3359007 | — | IC50 | - | — | - | |
| CHEMBL3359008 | — | IC50 | - | — | - | |
| CHEMBL3359021 | — | IC50 | - | — | - | |
| CHEMBL3359009 | — | IC50 | - | — | - | |
| CHEMBL3359010 | — | IC50 | - | — | - | |
| CHEMBL3359018 | — | IC50 | - | — | - | |
| CHEMBL3359016 | — | IC50 | - | — | - | |
| CHEMBL3359012 | — | IC50 | - | — | - | |
| CHEMBL3359013 | — | IC50 | - | — | - |