Assay Detail
Binding
CHEMBL3380041
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Inhibition of human recombinant ADAM17 using Mca-PLAQAV-Dpa-RSSSR-NH2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹⁸F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.11 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355722 | — | — | 1 | 8.24 |
| CHEMBL3355723 | — | — | 1 | 7.61 |
| CHEMBL3355724 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355722 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3355723 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL3355724 | — | IC50 | = | 3260.0 | nM | 5.49 |