Assay Detail
Functional
CHEMBL3380157
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse S1P1 receptor assessed as cAMP accumulation by HTRF assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sphingosine 1-phosphate receptor 1 (CHEMBL1914262) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 10.25 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3359522 | — | — | 1 | 10.30 |
| CHEMBL3359523 | — | — | 1 | 10.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3359522 | — | EC50 | = | 0.05 | nM | 10.30 |
| CHEMBL3359523 | — | EC50 | = | 0.064 | nM | 10.19 |