Assay Detail
Binding
CHEMBL3380228
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at MDR1 (unknown origin) expressed in MDCK-MDR1 cells by Calcein-AM assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK-MDR1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 5.71 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3354882 | — | — | 1 | 6.68 |
| CHEMBL3355378 | — | — | 1 | 6.16 |
| CHEMBL260599 | — | — | 1 | 6.09 |
| CHEMBL3355373 | — | — | 1 | 6.06 |
| CHEMBL3355376 | — | — | 1 | 6.02 |
| CHEMBL3355370 | — | — | 1 | 5.98 |
| CHEMBL3355364 | — | — | 1 | 5.95 |
| CHEMBL3355367 | — | — | 1 | 5.87 |
| CHEMBL3355375 | — | — | 1 | 5.87 |
| CHEMBL3355377 | — | — | 1 | 5.76 |
| CHEMBL3352847 | — | — | 1 | 5.75 |
| CHEMBL3355363 | — | — | 1 | 5.54 |
| CHEMBL3355368 | — | — | 1 | 5.53 |
| CHEMBL3355374 | — | — | 1 | 5.46 |
| CHEMBL3355366 | — | — | 1 | 5.35 |
| CHEMBL3355371 | — | — | 1 | 5.34 |
| CHEMBL3355372 | — | — | 1 | 5.33 |
| CHEMBL3355365 | — | — | 1 | 5.18 |
| CHEMBL3355362 | — | — | 1 | 5.14 |
| CHEMBL3355369 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3354882 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3355378 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL260599 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL3355373 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3355376 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL3355370 | — | EC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL3355364 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL3355367 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL3355375 | — | EC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL3355377 | — | EC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL3352847 | — | EC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL3355363 | — | EC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL3355368 | — | EC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL3355374 | — | EC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL3355366 | — | EC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL3355371 | — | EC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL3355372 | — | EC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL3355365 | — | EC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL3355362 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3355369 | — | EC50 | = | 7660.0 | nM | 5.12 |