Assay Detail
Functional
CHEMBL3380390
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Antiproliferative activity against human HeLa cells after 72 hrs by coulter counting analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.60 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2391219 | — | — | 1 | 6.67 |
| CHEMBL3313947 | — | — | 1 | 6.61 |
| CHEMBL2391218 | — | — | 1 | 6.43 |
| CHEMBL2391207 | — | — | 1 | 6.41 |
| CHEMBL2391205 | — | — | 1 | 6.19 |
| CHEMBL2391214 | — | — | 1 | 6.08 |
| CHEMBL2391212 | — | — | 1 | 6.04 |
| CHEMBL2012925 | — | — | 1 | 6.00 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.77 |
| CHEMBL2391213 | — | — | 1 | 5.54 |
| CHEMBL2391204 | — | — | 1 | 5.42 |
| CHEMBL2391209 | — | — | 1 | 5.35 |
| CHEMBL2391222 | — | — | 1 | 5.26 |
| CHEMBL2391216 | — | — | 1 | 5.25 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.67 |
| CHEMBL2391206 | — | — | 1 | 4.57 |
| CHEMBL2391215 | — | — | 1 | 4.40 |
| CHEMBL2391208 | — | — | 1 | 4.22 |
| CHEMBL2391211 | — | — | 1 | - |
| CHEMBL2391217 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2391219 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL3313947 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL2391218 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2391207 | — | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL2391205 | — | IC50 | = | 649.0 | nM | 6.19 |
| CHEMBL2391214 | — | IC50 | = | 822.0 | nM | 6.08 |
| CHEMBL2391212 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL2012925 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL852 | MELPHALAN | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2391213 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL2391204 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL2391209 | — | IC50 | = | 4430.0 | nM | 5.35 |
| CHEMBL2391222 | — | IC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL2391216 | — | IC50 | = | 5610.0 | nM | 5.25 |
| CHEMBL140 | CURCUMIN | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL2391206 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL2391215 | — | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL2391208 | — | IC50 | = | 59900.0 | nM | 4.22 |
| CHEMBL2391211 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL2391217 | — | IC50 | = | 219000.0 | nM | - |