Assay Detail
Functional
CHEMBL3380394
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Cytotoxicity against human HCC2998 cells assessed as inhibition of tumor growth after 24 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC 2998 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.19 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3313947 | — | — | 1 | 7.00 |
| CHEMBL2391219 | — | — | 1 | 7.00 |
| CHEMBL2391214 | — | — | 1 | 6.89 |
| CHEMBL2391212 | — | — | 1 | 6.77 |
| CHEMBL2391222 | — | — | 1 | 6.75 |
| CHEMBL2012925 | — | — | 1 | 6.72 |
| CHEMBL2391213 | — | — | 1 | 6.52 |
| CHEMBL2391205 | — | — | 1 | 6.51 |
| CHEMBL2391207 | — | — | 1 | 6.21 |
| CHEMBL2391221 | — | — | 1 | 5.76 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.24 |
| CHEMBL2391206 | — | — | 1 | 4.78 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3313947 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2391219 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2391214 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2391212 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2391222 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2012925 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2391213 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2391205 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2391207 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2391221 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL2391206 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL852 | MELPHALAN | IC50 | = | 52500.0 | nM | 4.28 |