Assay Detail
Functional
CHEMBL3380398
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Antileukemic activity against human HL-60(TB) cells assessed as inhibition of tumor growth after 24 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60(TB) |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.29 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2391219 | — | — | 1 | 7.40 |
| CHEMBL3313947 | — | — | 1 | 7.16 |
| CHEMBL2391214 | — | — | 1 | 6.96 |
| CHEMBL2391205 | — | — | 1 | 6.72 |
| CHEMBL2012925 | — | — | 1 | 6.70 |
| CHEMBL2391213 | — | — | 1 | 6.64 |
| CHEMBL2391222 | — | — | 1 | 6.60 |
| CHEMBL2391212 | — | — | 1 | 6.54 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 6.42 |
| CHEMBL2391207 | — | — | 1 | 5.95 |
| CHEMBL2391221 | — | — | 1 | 5.76 |
| CHEMBL2391206 | — | — | 1 | 4.88 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2391219 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3313947 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2391214 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2391205 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2012925 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2391213 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2391222 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2391212 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL852 | MELPHALAN | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2391207 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL2391221 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL2391206 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 85100.0 | nM | 4.07 |