Assay Detail
Functional
CHEMBL3380435
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Cytotoxicity against human MV4-11 cells assessed as cell viability after 48 hrs by MTT assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 7.51 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3329685 | — | — | 1 | 8.70 |
| CHEMBL3329684 | — | — | 1 | 8.62 |
| CHEMBL3329668 | — | — | 1 | 8.38 |
| CHEMBL3329672 | — | — | 1 | 8.28 |
| CHEMBL3329669 | — | — | 1 | 8.28 |
| CHEMBL3329673 | — | — | 1 | 8.21 |
| CHEMBL3329675 | — | — | 1 | 8.19 |
| CHEMBL3329682 | — | — | 1 | 8.09 |
| CHEMBL215152 | DEFOSBARASERTIB | 2.0 | 1 | 8.07 |
| CHEMBL3329678 | — | — | 1 | 7.97 |
| CHEMBL3329679 | — | — | 1 | 7.96 |
| CHEMBL3329676 | — | — | 1 | 7.95 |
| CHEMBL3329664 | — | — | 1 | 7.92 |
| CHEMBL3329660 | — | — | 1 | 7.85 |
| CHEMBL3329677 | — | — | 1 | 7.82 |
| CHEMBL3329680 | — | — | 1 | 7.78 |
| CHEMBL3329683 | — | — | 1 | 7.75 |
| CHEMBL3329681 | — | — | 1 | 7.75 |
| CHEMBL3329656 | — | — | 1 | 7.71 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.61 |
| CHEMBL3329671 | — | — | 1 | 7.58 |
| CHEMBL3329652 | — | — | 1 | 7.53 |
| CHEMBL3329657 | — | — | 1 | 7.50 |
| CHEMBL3329670 | — | — | 1 | 7.46 |
| CHEMBL3329674 | — | — | 1 | 7.45 |
| CHEMBL3330971 | — | — | 1 | 7.34 |
| CHEMBL3329665 | — | — | 1 | 7.20 |
| CHEMBL3329662 | — | — | 1 | 6.82 |
| CHEMBL3329659 | — | — | 1 | 6.72 |
| CHEMBL3330970 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3329685 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3329684 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3329668 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3329672 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3329669 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3329673 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3329675 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3329682 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL215152 | DEFOSBARASERTIB | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL3329678 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL3329679 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3329676 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL3329664 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3329660 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL3329677 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL3329680 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL3329683 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL3329681 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL3329656 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL535 | SUNITINIB | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL3329671 | — | IC50 | = | 26.1 | nM | 7.58 |
| CHEMBL3329652 | — | IC50 | = | 29.3 | nM | 7.53 |
| CHEMBL3329657 | — | IC50 | = | 31.6 | nM | 7.50 |
| CHEMBL3329670 | — | IC50 | = | 34.6 | nM | 7.46 |
| CHEMBL3329674 | — | IC50 | = | 35.9 | nM | 7.45 |
| CHEMBL3330971 | — | IC50 | = | 45.5 | nM | 7.34 |
| CHEMBL3329665 | — | IC50 | = | 62.8 | nM | 7.20 |
| CHEMBL3329662 | — | IC50 | = | 149.9 | nM | 6.82 |
| CHEMBL3329659 | — | IC50 | = | 190.7 | nM | 6.72 |
| CHEMBL3330970 | — | IC50 | = | 228.2 | nM | 6.64 |
| CHEMBL3329658 | — | IC50 | = | 233.5 | nM | 6.63 |
| CHEMBL3329655 | — | IC50 | = | 239.9 | nM | 6.62 |
| CHEMBL3329651 | — | IC50 | = | 256.3 | nM | 6.59 |
| CHEMBL3329663 | — | IC50 | = | 261.4 | nM | 6.58 |
| CHEMBL3361346 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL3329661 | — | IC50 | = | 284.9 | nM | 6.54 |
| CHEMBL3329650 | — | IC50 | = | 357.2 | nM | 6.45 |
| CHEMBL3330969 | — | IC50 | = | 376.8 | nM | 6.42 |
| CHEMBL3329667 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3329666 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3329653 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3330976 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3330975 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3361347 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3330972 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3330968 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3329687 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3329686 | — | IC50 | > | 500.0 | nM | - |