Assay Detail
Binding
CHEMBL3380548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged full length ITK (unknown origin) using BLK peptide as substrate after 35 mins
30
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.88 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3263053 | — | — | 1 | 10.00 |
| CHEMBL3298373 | — | — | 1 | 9.70 |
| CHEMBL3298371 | — | — | 1 | 9.15 |
| CHEMBL3298375 | — | — | 1 | 9.15 |
| CHEMBL3298370 | — | — | 1 | 9.10 |
| CHEMBL3263036 | — | — | 1 | 8.96 |
| CHEMBL3298376 | — | — | 1 | 8.92 |
| CHEMBL3298369 | — | — | 2 | 8.52 |
| CHEMBL3298288 | — | — | 1 | 8.28 |
| CHEMBL3298374 | — | — | 1 | 8.21 |
| CHEMBL3298293 | — | — | 2 | 8.10 |
| CHEMBL3298286 | — | — | 2 | 8.08 |
| CHEMBL3298291 | — | — | 1 | 8.00 |
| CHEMBL3298372 | — | — | 1 | 7.82 |
| CHEMBL3298287 | — | — | 2 | 7.66 |
| CHEMBL3298285 | — | — | 1 | 7.51 |
| CHEMBL3298368 | — | — | 2 | 7.43 |
| CHEMBL3298367 | — | — | 2 | 7.38 |
| CHEMBL3262780 | — | — | 1 | 7.37 |
| CHEMBL3298289 | — | — | 1 | 7.16 |
| CHEMBL3298366 | — | — | 1 | 7.12 |
| CHEMBL3298290 | — | — | 1 | 6.75 |
| CHEMBL3298292 | — | — | 2 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3263053 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL3298373 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL3298371 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3298375 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3298370 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL3263036 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL3298376 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL3298369 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3298288 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL3298374 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL3298293 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL3298286 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL3298286 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL3298291 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3298372 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL3298287 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3298285 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3298368 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL3298367 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL3262780 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL3298367 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL3298289 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL3298366 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL3298287 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL3298293 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3298290 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3298292 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3298368 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL3298369 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL3298292 | — | Ki | = | 280.0 | nM | 6.55 |