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Assay Detail

CHEMBL3380748

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Functional
Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of parasite growth after 72 hrs by cell based assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Antimalarial activity of abietane ferruginol analogues possessing a phthalimide group.
González MA, Clark J, Connelly M, Rivas F.
Bioorg Med Chem Lett (2014) 24 : 5234 -5237
PubMed 25316317 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 14 5.23 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3338082 1 6.70
CHEMBL76 CHLOROQUINE 4.0 1 6.16
CHEMBL197308 FERRUGINOL 1 5.88
CHEMBL3338084 1 5.40
CHEMBL3338081 1 4.82
CHEMBL3338083 1 4.82
CHEMBL3338085 1 4.82
CHEMBL1277662 18-OXOFERRUGINOL 1 4.82
CHEMBL3338086 1 4.82
CHEMBL3338087 1 4.82
CHEMBL3338088 1 4.82
CHEMBL3338089 1 4.82
CHEMBL555017 GAMBOGIC ACID 1 -
CHEMBL388978 STAUROSPORINE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3338082 EC50 = 201.0 nM 6.70
CHEMBL76 CHLOROQUINE EC50 = 690.0 nM 6.16
CHEMBL197308 FERRUGINOL EC50 = 1330.0 nM 5.88
CHEMBL3338084 EC50 = 4000.0 nM 5.40
CHEMBL3338081 EC50 = 15000.0 nM 4.82
CHEMBL3338083 EC50 = 15000.0 nM 4.82
CHEMBL3338085 EC50 = 15000.0 nM 4.82
CHEMBL1277662 18-OXOFERRUGINOL EC50 = 15000.0 nM 4.82
CHEMBL3338086 EC50 = 15000.0 nM 4.82
CHEMBL3338087 EC50 = 15000.0 nM 4.82
CHEMBL3338088 EC50 = 15000.0 nM 4.82
CHEMBL3338089 EC50 = 15000.0 nM 4.82
CHEMBL555017 GAMBOGIC ACID EC50 - -
CHEMBL388978 STAUROSPORINE EC50 - -