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Assay Detail

CHEMBL3380896

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against Plasmodium falciparum assessed as growth inhibition
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Exploring in vitro and in vivo Hsp90 inhibitors activity against human protozoan parasites.
Giannini G, Battistuzzi G.
Bioorg Med Chem Lett (2015) 25 : 462 -465
PubMed 25547934 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.61 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3234764 1 9.00
CHEMBL3234770 1 9.00
CHEMBL3353321 1 8.70
CHEMBL76 CHLOROQUINE 4.0 1 8.52
CHEMBL3353320 1 8.40
CHEMBL3353319 1 7.92
CHEMBL1941077 1 7.77
CHEMBL1941055 1 7.60
CHEMBL1940941 1 7.58
CHEMBL1941052 1 7.54
CHEMBL1941061 1 7.46
CHEMBL1941079 1 7.44
CHEMBL1941050 1 7.43
CHEMBL1940934 1 6.93
CHEMBL3233488 1 5.34
CHEMBL3233485 1 5.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3234764 IC50 = 1.0 nM 9.00
CHEMBL3234770 IC50 = 1.0 nM 9.00
CHEMBL3353321 IC50 = 2.0 nM 8.70
CHEMBL76 CHLOROQUINE IC50 = 3.0 nM 8.52
CHEMBL3353320 IC50 = 4.0 nM 8.40
CHEMBL3353319 IC50 = 12.0 nM 7.92
CHEMBL1941077 IC50 = 17.0 nM 7.77
CHEMBL1941055 IC50 = 25.0 nM 7.60
CHEMBL1940941 IC50 = 26.0 nM 7.58
CHEMBL1941052 IC50 = 29.0 nM 7.54
CHEMBL1941061 IC50 = 35.0 nM 7.46
CHEMBL1941079 IC50 = 36.0 nM 7.44
CHEMBL1941050 IC50 = 37.0 nM 7.43
CHEMBL1940934 IC50 = 117.0 nM 6.93
CHEMBL3233488 IC50 = 4525.0 nM 5.34
CHEMBL3233485 IC50 = 7265.0 nM 5.14