Assay Detail
Binding
CHEMBL3381315
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Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α<alpha>1 and 5-HT1A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.72 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342871 | — | — | 1 | 9.04 |
| CHEMBL3342853 | — | — | 1 | 8.33 |
| CHEMBL3342870 | — | — | 1 | 8.24 |
| CHEMBL3342868 | — | — | 1 | 8.15 |
| CHEMBL3342857 | — | — | 1 | 8.09 |
| CHEMBL3342872 | — | — | 1 | 8.01 |
| CHEMBL3342867 | — | — | 1 | 7.97 |
| CHEMBL3342860 | — | — | 1 | 7.96 |
| CHEMBL3342866 | — | — | 1 | 7.91 |
| CHEMBL3342874 | — | — | 1 | 7.88 |
| CHEMBL3342852 | — | — | 1 | 7.83 |
| CHEMBL3342875 | — | — | 1 | 7.72 |
| CHEMBL3342859 | — | — | 1 | 7.69 |
| CHEMBL3342858 | — | — | 1 | 7.64 |
| CHEMBL3342873 | — | — | 1 | 7.63 |
| CHEMBL3341769 | — | — | 1 | 7.60 |
| CHEMBL3342869 | — | — | 1 | 7.58 |
| CHEMBL3342863 | — | — | 1 | 7.57 |
| CHEMBL3342861 | — | — | 1 | 7.55 |
| CHEMBL3342876 | — | — | 1 | 7.45 |
| CHEMBL3342856 | — | — | 1 | 7.43 |
| CHEMBL3342862 | — | — | 1 | 7.40 |
| CHEMBL3342854 | — | — | 1 | 7.37 |
| CHEMBL3342855 | — | — | 1 | 7.29 |
| CHEMBL3342864 | — | — | 1 | 7.05 |
| CHEMBL3342865 | — | — | 1 | 6.38 |
| CHEMBL2234448 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342871 | — | Ki | = | 0.912 | nM | 9.04 |
| CHEMBL3342853 | — | Ki | = | 4.677 | nM | 8.33 |
| CHEMBL3342870 | — | Ki | = | 5.754 | nM | 8.24 |
| CHEMBL3342868 | — | Ki | = | 7.079 | nM | 8.15 |
| CHEMBL3342857 | — | Ki | = | 8.128 | nM | 8.09 |
| CHEMBL3342872 | — | Ki | = | 9.772 | nM | 8.01 |
| CHEMBL3342867 | — | Ki | = | 10.72 | nM | 7.97 |
| CHEMBL3342860 | — | Ki | = | 10.96 | nM | 7.96 |
| CHEMBL3342866 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL3342874 | — | Ki | = | 13.18 | nM | 7.88 |
| CHEMBL3342852 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL3342875 | — | Ki | = | 19.05 | nM | 7.72 |
| CHEMBL3342859 | — | Ki | = | 20.42 | nM | 7.69 |
| CHEMBL3342858 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL3342873 | — | Ki | = | 23.44 | nM | 7.63 |
| CHEMBL3341769 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL3342869 | — | Ki | = | 26.3 | nM | 7.58 |
| CHEMBL3342863 | — | Ki | = | 26.92 | nM | 7.57 |
| CHEMBL3342861 | — | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL3342876 | — | Ki | = | 35.48 | nM | 7.45 |
| CHEMBL3342856 | — | Ki | = | 37.15 | nM | 7.43 |
| CHEMBL3342862 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL3342854 | — | Ki | = | 42.66 | nM | 7.37 |
| CHEMBL3342855 | — | Ki | = | 51.29 | nM | 7.29 |
| CHEMBL3342864 | — | Ki | = | 89.13 | nM | 7.05 |
| CHEMBL3342865 | — | Ki | = | 416.87 | nM | 6.38 |
| CHEMBL2234448 | — | Ki | > | 1000.0 | nM | - |