Assay Detail
Functional
CHEMBL3381690
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Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-8 expression pretreated 1 hr before LPS challenge followed by incubated for 16 hrs by flow cytometry
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-inflammatory diterpenoids from the root bark of Acanthopanax gracilistylus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3358078 | — | — | 1 | 9.00 |
| CHEMBL3358082 | — | — | 1 | 8.52 |
| CHEMBL598784 | — | — | 1 | 8.22 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.05 |
| CHEMBL489140 | KAURENOIC ACID | — | 1 | 5.11 |
| CHEMBL3358079 | — | — | 1 | - |
| CHEMBL2420226 | — | — | 1 | - |
| CHEMBL3358080 | — | — | 1 | - |
| CHEMBL3358081 | — | — | 1 | - |
| CHEMBL3358083 | — | — | 1 | - |
| CHEMBL3358084 | — | — | 1 | - |
| CHEMBL3358085 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3358078 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3358082 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL598784 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL489140 | KAURENOIC ACID | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL3358079 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2420226 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3358080 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3358081 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3358083 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3358084 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3358085 | — | IC50 | > | 10000.0 | nM | - |